Identification and heterologous expression of an NRPS biosynthetic gene cluster responsible for the production of the pyrazinones Ichizinone A, B and C

Patrick Oberhäuser, Maksym Myronovskyi, Marc Stierhof, Oleksandr Gromyko, Andriy Luzhetskyy

Description of Streptomyces explomaris sp. nov., isolated from the coastal soil rhizosphere of Juniperus excelsa and reclassification of Streptomyces libani as a later heterotypic synonym of Streptomyces nigrescens

Wei Shu, Christian Rückert-Reed, Olexandr Gromyko, Stepan Tistechok, Jörn Kalinowski, Andriy Luzhetskyy, Christoph Wittmann

Gromomycins: An Unprecedented Class of Triterpene Antibiotics Produced by a Novel Biosynthetic Pathway

Stepan Tistechok, Dmytro Bratiichuk, Hilda Sucipto, Nils Gummerlich, Marc Stierhof, Oleksandr Gromyko, Franziska Fries, Victor Fedorenko, Rolf Müller, Josef Zapp, Maksym Myronovskyi, Andriy Luzhetskyy

Uncovering the genetic basis of antiviral polyketide limocrocin biosynthesis through heterologous expression

Sofiia Melnyk, Marc Stierhof, Dmytro Bratiichuk, Franziska Fries, Rolf Müller, Yuriy Rebets, Andriy Luzhetskyy, Bohdan Ostash

Streptomyces as a versatile host platform for heterologous production of microbial natural products

Constanze Lasch, Maksym Myronovskyi, Andriy Luzhetskyy

Gene amir_2071 of Actinosynnema mirum DSM 43827 encodes a dimethylallyltryptophan synthase superfamily protein responsible for the production of prenylated tyrosine

Sofiia Melnyk, Yuriy Rebets, Dmytro Bratiichuk, Andriy Luzhetskyy, Bohdan Ostash

Metabolic engineering of Streptomyces explomaris for increased production of the reverse antibiotic nybomycin

Wei Shu, Julian Stegmüller, Marta Rodriguez-Estevez, Christian Rückert-Reed, Jörn Kalinowski, Oleksandr Gromyko, Yuriy Rebets, Andriy Luzhetskyy, Christoph Wittmann

Heterologous biosynthetic crosstalk with the native mansouramycin cluster in Streptomyces albus Del14 reveals unexpected metabolites

Marc Stierhof, Liliya Horbal, Patrick Oberhäuser, Anja Palusczak, Peyton Cox, Maria Lopatniuk, Christopher Ruf, Josef Zapp, Andriy Luzhetskyy