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2020

Publications

Targeted Genome Mining-From Compound Discovery to Biosynthetic Pathway Elucidation

Nils Gummerlich, Yuriy Rebets, Constanze Paulus, Josef Zapp, Andriy Luzhetskyy

Non-Heme Monooxygenase ThoJ Catalyzes Thioholgamide β-Hydroxylation

Asfandyar Sikandar, Maria Lopatniuk, Andriy Luzhetskyy, Jesko Koehnke

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The bottromycin epimerase BotH defines a group of atypical α/β-hydrolase-fold enzymes

Asfandyar Sikandar, Laura Franz, Sebastian Adam, Javier Santos-Aberturas, Liliya Horbal, Andriy Luzhetskyy, Andrew W Truman, Olga V Kalinina, Jesko Koehnke

Secondary metabolites overproduction through transcriptional gene cluster refactoring

Liliya Horbal, Filipe Marques, Suvd Nadmid, Marta V Mendes, Andriy Luzhetskyy

Microparticles globally reprogram Streptomyces albus toward accelerated morphogenesis, streamlined carbon core metabolism, and enhanced production of the antituberculosis polyketide pamamycin

Martin Kuhl, Lars Gläser, Yuriy Rebets, Christian Rückert, Namrata Sarkar, Thomas Hartsch, Jörn Kalinowski, Andriy Luzhetskyy, Christoph Wittmann

Identification of a Biosynthetic Gene Cluster Responsible for the Production of a New Pyrrolopyrimidine Natural Product-Huimycin

Hui Shuai, Maksym Myronovskyi, Suvd Nadmid, Andriy Luzhetskyy

Thioholgamide A, a New Anti-Proliferative Anti-Tumor Agent, Modulates Macrophage Polarization and Metabolism

Charlotte Dahlem, Wei Xiong Siow, Maria Lopatniuk, William K F Tse, Sonja M Kessler, Susanne H Kirsch, Jessica Hoppstädter, Angelika M Vollmar, Rolf Müller, Andriy Luzhetskyy, Karin Bartel, Alexandra K Kiemer

Identification and Heterologous Expression of the Albucidin Gene Cluster from the Marine Strain Streptomyces Albus Subsp. Chlorinus NRRL B-24108

Maksym Myronovskyi, Birgit Rosenkränzer, Marc Stierhof, Lutz Petzke, Tobias Seiser, Andriy Luzhetskyy

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Engineering of Streptomyces lividans for heterologous expression of secondary metabolite gene clusters

Yousra Ahmed, Yuriy Rebets, Marta Rodríguez Estévez, Josef Zapp, Maksym Myronovskyi, Andriy Luzhetskyy

Dudomycins: New Secondary Metabolites Produced After Heterologous Expression of an Nrps Cluster from Streptomyces albus ssp. Chlorinus Nrrl B-24108

Constanze Lasch, Marc Stierhof, Marta Rodríguez Estévez, Maksym Myronovskyi, Josef Zapp, Andriy Luzhetskyy

Loseolamycins: A Group of New Bioactive Alkylresorcinols Produced after Heterologous Expression of a Type III PKS from Micromonospora endolithica

Constanze Lasch, Nils Gummerlich, Maksym Myronovskyi, Anja Palusczak, Josef Zapp, Andriy Luzhetskyy

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Perquinolines A-C: Unprecedented Bacterial Tetrahydroisoquinolines Involving an Intriguing Biosynthesis

Yuriy Rebets, Suvd Nadmid, Constanze Paulus, Charlotte Dahlem, Jennifer Herrmann, Harald Hübner, Christian Rückert, Alexandra K Kiemer, Peter Gmeiner, Jörn Kalinowski, Rolf Müller, Andriy Luzhetskyy

Engineering Corynebacterium glutamicum with a comprehensive genomic library and phage-based vectors

Filipe Marques, Andriy Luzhetskyy, Marta V Mendes

Bioactive flavonoids from plant extract of Pyrethrum pulchrum and its acute toxicity

Uugangerel Erdenetsogt, Suvd Nadmid, Constanze Paulus, Ganchimeg Chanagsuren, Erdenechimeg Dolgor, Choijamts Gotov, Hans-Martin Dahse, Andriy Luzhetskyy, Enkhmaa Dagvadorj

Novel Fredericamycin Variant Overproduced by a Streptomycin-resistant Streptomyces albus subsp. chlorinus Strain

Marta Rodríguez Estévez, Maksym Myronovskyi, Birgit Rosenkränzer, Thomas Paululat, Lutz Petzke, Jeanette Ristau, Andriy Luzhetskyy

Baikalomycins A-C, New Aquayamycin-Type Angucyclines Isolated from Lake Baikal Derived Streptomyces sp. IB201691-2A

Irina Voitsekhovskaia, Constanze Paulus, Charlotte Dahlem, Yuriy Rebets, Suvd Nadmid, Josef Zapp, Denis Axenov-Gribanov, Christian Rückert, Maxim Timofeyev, Jörn Kalinowski, Alexandra K Kiemer, Andriy Luzhetskyy

Benzanthric Acid, a Novel Metabolite From Streptomyces albus Del14 Expressing the Nybomycin Gene Cluster

Marta Rodríguez Estévez, Nils Gummerlich, Maksym Myronovskyi, Josef Zapp, Andriy Luzhetskyy

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Pharmaceutical Biotechnology

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