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2005

Publications

LanV, a bifunctional enzyme: aromatase and ketoreductase during landomycin A biosynthesis

Almuth Mayer, Takaaki Taguchi, Anton Linnenbrink, Carsten Hofmann, Andriy Luzhetskyy, Andreas Bechthold

LanGT2 Catalyzes the First Glycosylation Step during landomycin A biosynthesis

Andriy Luzhetskyy, Takaaki Taguchi, Marta Fedoryshyn, Clemens Dürr, Sven-Eric Wohlert, Volodymyr Novikov, Andreas Bechthold

landomycin M and O.jpg

Generation of novel landomycins M and O through targeted gene disruption

Andriy Luzhetskyy, Lili Zhu, Miranda Gibson, Marta Fedoryshyn, Clemens Dürr, Carsten Hofmann, Dirk Hoffmeister, Bohdan Ostash, Cynthia Mattingly, Val Adams, Victor Fedorenko, Jürgen Rohr, Andreas Bechthold

LndI protein.JPG

DNA-binding activity of LndI protein and temporal expression of the gene that upregulates landomycin E production in Streptomyces globisporus 1912

Yu Rebets, B Ostash, A Luzhetskyy, S Kushnir, M Fukuhara, A Bechthold, M Nashimoto, T Nakamura, V Fedorenko

Glycosyltransferases and other tailoring enzymes as tools for the generation of novel compounds

A Bechthold, G Weitnauer, A Luzhetskyy, M Berner, C Bihlmeier, R Boll, C Dürr, A Frerich, C Hofmann, A Mayer, I Treede, A Vente, M Luzhetskyy

It works: combinatorial biosynthesis for generating novel glycosylated compounds

Andriy Luzhetskyy, Andreas Bechthold

iteratively active landomycin A.gif

Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A

Andriy Luzhetskyy, Marta Fedoryshyn, Clemens Dürr, Takaaki Taguchi, Volodymyr Novikov, Andreas Bechthold

Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone

Lili Zhu, Bohdan Ostash, Uwe Rix, Mohammad Nur-E-Alam, Almuth Mayers, Andriy Luzhetskyy, Carmen Mendez, Jose A Salas, Andreas Bechthold, Victor Fedorenko, Jürgen Rohr

PCR detectign gene.JPG

The Use of PCR for Detecting Genes That Encode Type I Polyketide Synthases in Genomes of Actinomycetes

B. E. Ostash, S. V. Ogonyan, A. N. Luzhetskyy, A. Bechthold, V. A. Fedorenko

Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides

Andriy Luzhetskyy, Andreas Vente, Andreas Bechthold

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Saarland University

Pharmaceutical Biotechnology

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66123 Saarbrücken

Germany

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